胰臟腫瘤

陳瑞灝醫師

*胰臟腫瘤可大體分成兩大類

1.外分泌腫瘤:大部分是duct cell origin,極少數源於acinar cell

2.內分泌腫瘤:
insulinoma
gastrinoma
VIPoma
glucagonoma
somatostatinoma
GRFoma
PPoma and nonfunctional tumors

*由於大部分的胰腫瘤均來duct cell,我們的重點乃放在duct cell origin的腫瘤:

1.Benign solid adenoma
-cystadenoma
2.Malignant solid adenocarcinoma
-cystadenocarcinoma

*pancreatic adenocorcinoma
症狀:常見的症狀為黃疸、上腹痛、體重減輕、消化不良,部分病人併發胰臟炎(急性或慢性均有)
courvoisier's sign:a distended and palpable gall bladder,多見於胰頭癌
Trousseau's syndrome:migratory thrombophlebitis,多見於胰體部及尾部的癌
R診斷:EUS. ERCP. CT, Abdominal ultrasound,fine needle aspiration of tumor,tumor marker
‾治療

a.手術療法:只有10%∼20%的病人,可以手術切除,且預後不佳
b. 化學治療
c.放射+化學治療
d. 對於無法切除的胰癌所致的阻塞性黃疸:
by-pass surgery(biliary by-pass+gastrojejunostomy)或endoscopic stenting(or PTCD with stenting)

*cystadenoma and cystadenocarcinoma

1.Mucinous cystadenoma or cystadenocarcinoma:
 a. Mucinous lesions have malignant potential and should be resected
 b. Found mainly in younger women

2.serous cystadenoma(Microcystic):
 a. Middle-aged or elderly woman
  b. Benign lesions


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